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prothrombin time
The prothrombin time (PT) — along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) — are assays evaluating the ''extrinsic pathway'' of coagulation. This test is also called "ProTime INR" and "PT/INR". They are used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage, and vitamin K status. PT measures factors I (fibrinogen), II (prothrombin), V, VII, and X. It is used in conjunction with the activated partial thromboplastin time (aPTT) which measures the ''intrinsic pathway'' and common pathway.
==Laboratory measurement==
The reference range for prothrombin time depends on the analytical method used, but is usually around 12–13 seconds (results should always be interpreted using the reference range from the laboratory that performed the test), and the INR in absence of anticoagulation therapy is 0.8-1.2. The target range for INR in anticoagulant use (e.g. warfarin) is 2 to 3. In some cases, if more intense anticoagulation is thought to be required, the target range may be as high as 2.5-3.5 depending on the indication for anticoagulation. In The Netherlands, the target INR for 'low intensity' is between 2.5 and 3.5 and for 'high intensity' between 3.0 and 4.0.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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